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HDI may refer to:
- Human Development Index, a United Nations measure of well-being in a country
- Help Desk Institute, a trade association
- PSA HDi engine, a diesel automobile engine by Peugeot/Citroën
- Hexamethylene diisocyanate, an organic compound used to make polymers such as polyurethane
- HDi Interactive Format (formerly iHD), a trademark for Microsoft's implementation of advanced interactivity for HD DVD
- Histone deacetylase inhibitor, compounds used in psychiatry and neurology, and with anticancer potential
See also:
- HDI-45 connector, a video connector by Apple Inc.
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